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These react further with GSH and O 2 to produce superoxide radicals (O2 .- ), which dismutate to yield H 2 O 2 , in turn driving APEX2 activity

Free GSH concentration in the sample is calculated from the difference between the total GSH determined and the GSH generated from GSSG

Determinants of body weight regulation in humans

The authors of one trial (95) included in the above-mentioned meta-analysis (89) noted that little cognitive decline was observed in the placebo group over their two-year trial, which may have limited their power to detect an effect of the B-vitamin intervention (95)