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Previous training ameliorated renal function and resulted in fewer tubulointerstitial lesions, less inflammation (as evidenced by decreased macrophage infiltration), and diminished IL-1, as well as decreased urinary excretion of MCP-1 and TGF-

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19) (Enroth et al

This interaction is thought to activate key biological pathways involved in wound healing, collagen synthesis, hair growth, immune function, and angiogenesis (the formation of new blood vessels)