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ROS produced via ferritinophagy or iron-dependent ROS production have a role in RANKL-induced osteoclast differentiation, but unregulated ROS production can result in ferroptosis-mediated death

GH treatment also increases the number of IGF-immunoreactive cells and IGF-I messenger RNA expression in the proliferative zone of the growth plate

"BPC" stands for "Body Protection Compound." In preclinical work it is proposed to act through several overlapping pathways, including promotion of new blood-vessel growth (angiogenesis), modulation of nitric-oxide signaling, and anti-inflammatory activity, rather than through one well-defined receptor mechanism the way a conventional small-molecule drug does