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de la Cuesta-Zuluaga J, Mueller NT, Corrales-Agudelo V et al (2017) Metformin is associated with higher relative abundance of mucin-degrading Akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut

Researchers modified the original peptide structure to create longer-acting formulations with various strategies: liraglutide (once daily) uses fatty acid albumin-binding, dulaglutide (once weekly) employs an Fc-fusion approach, exenatide extended-release (Bydureon, once weekly) utilises microsphere technology, and semaglutide (once weekly) incorporates fatty acid modifications

However, unlike small molecule drugs conjugated with antibodies, in the case of MariTide, peptides are conjugated

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