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Long et al., 2024), including the NADPH/FSP1/CoQ10 pathway, the dihydroorotate dehydrogenase (DHODH) pathway, the GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4)/dihydrofolate reductase (DHFR) pathway, the membrane-bound O-acyltransferase 1/2 (MBOAT1/2) pathway, the peroxiredoxin 6 (PRDX6) pathway, and the 7-dehydrocholesterol (7-DHC) pathway

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Overall, the present findings, viewed in the context of corroborative and contrasting literature, reinforce the role of MPFF as a safe and effective agent for the rapid relief of symptoms in acute hemorrhoidal disease, while also illustrating the need for further work to delineate optimal dosing regimens and population-specific outcomes

On the other hand, iron is a prooxidant and can increase OS in the brain by participating in Fentons reaction and contributing to the formation of reactive oxygen species (ROS)