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Additionally, ontological terms related to CVD were observed, including hypertension (ACE, ADIPOQ, ADRB2, ALB, CASP3, CAV1, CRH, DPP4, FOS, GHRL, GNB3, INS, IRS1, LEP, LEPR, MGAM, NOS3, NPPA, NPY, POMC, PPARA, PPARG, PTH, REN, SST, VIP), calcium regulation in the cardiac cell (ADCY5-6-8, ADRB2, ARRB1-2, GNAQ, GNAS, GNB1-5, GNG11-13, GNG2-8, GNGT1), and process failing heart cytosolic accumulation of amino acids that can promote the activation of mTOR (AKT1, IRS1, IRS2)

109 RafatiA.NourzeiN.Karbalay-DoustS.NoorafshanA

doi:10.1007/s00204-021-03104-1