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This contrasts with targets in prior nanobody design studies [Bennett et al., 2025, Mille-Fragoso et al., 2025], which were selected for therapeutic relevance rather than novelty and have appeared in a bound context in the PDB at least once, exhibiting highly similar bound interfaces (Figure 2c)

In the regulated setting of mecasermin therapy, hypoglycemia is a recognized and monitored adverse effect, managed in part by co-administration with food

This innovative treatment uses laser technology to gently increase collagen production, resulting in a smoother skin surface

however, the powder will always dissolve much faster in warm or hot liquids