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Factors That Affect How Quickly B12 Injections Work Several key factors influence how fast youll notice results from B12 injections: Severity of deficiency: Those with severe B12 depletion may require more frequent injections before experiencing full benefits

Contraindications include known hypersensitivity to any component of the injection (including cobalt hypersensitivity), a history of severe reactions to thiamine/pyridoxine/cobalamin injections, and Lebers hereditary optic neuropathy (for B12-containing products)

Regular blood tests can check if you have enough B12