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That separation is the pharmacological reason the combination is rational

Because tirzepatide can reduce appetite, it is important to prioritize nutrient-dense meals instead of simply eating less

Kelly AS, Auerbach P, Barrientos-Prez M, et al

Retatrutide works by mimicking and activating three naturally occurring hormones in the body that play key roles in appetite regulation, blood sugar management and metabolism: GLP-1 (glucagon-like peptide-1) - Promotes feelings of fullness after eating, slows gastric emptying (the rate at which food leaves the stomach), and stimulates insulin secretion to help regulate blood sugar levels