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Proposed pathways include modulation of multiple neurotransmitter systems (influencing serotonin, dopamine, norepinephrine, GABA, glutamate levels), possible involvement of NMDA receptors, alpha-1 adrenergic signaling (e.g., potentiating pineal acetyltransferase activity), inhibition of somatostatin release via dopaminergic routes, reduced ACTH/cortisol for stress buffering, and stimulated growth hormone or somatoliberin secretion

In discussions around GLP 1 therapies, Huberman consistently points out that while pharmacology can drive significant fat loss, long term outcomes still depend on training, nutrition, and lifestyle structure

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[DOI] [PubMed] [Google Scholar] 300.Kim S., Islam J., Kim J., Koh Y., Hwang J., Kim H.T., Seong S.-Y