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Elevated SDF-1 and substance P levels are also suggested to induce apoptosis of the myocardium.60 In the SAVOR-TIMI 53 trial, attenuated HF elevation was detected when beta-blockers were used concomitantly.58,60 This might imply that chronic sympathetic activation might underlie the inferiority of DPP-4 inhibitors

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They usually respond well to 3050% lower doses than men, with more fat loss than muscle gain

We next considered the potential role of neoantigens resulting from SNVs in early disease by predicting neoantigens for patient-specific HLA-A, -B and -C alleles using NetMHC4.0 31,32 (see Supplementary Methods) and examining the loss of these predicted neoantigens due to LOH in late disease