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A retrospective cohort study found that semaglutide use was associated with a 44% reduced risk of incident cannabis use disorder (CUD) in patients with no prior history (hazard ratio [HR]: 0.56, 95% confidence interval [CI]: 0.420.75) and a 38% reduction in recurrent CUD diagnosis (HR: 0.62, 95% CI: 0.460.84) among patients with a prior history, compared to non-GLP-1RA medications [61]

NICE Technology Appraisal guidance (TA875 for semaglutide/Wegovy and TA664 for liraglutide/Saxenda) recommends these medications for weight management in adults with: A body mass index (BMI) of at least 35 kg/m and At least one weight-related comorbidity (such as type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea, or non-alcoholic fatty liver disease) For liraglutide (Saxenda), NICE TA664 specifies additional criteria including prediabetes (HbA1c 42-47 mmol/mol or fasting plasma glucose 5.5-6.9 mmol/L) or high risk of cardiovascular disease

[2] Semaglutide is not indicated for use in patients with type 1 diabetes or for treatment of diabetic ketoacidosis