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Then it increases to 4 mg once daily for 30 days, then 9 mg once daily for 30 days, and then reaching a maintenance dose of 25 mg once daily

The Evidence: Some small human studies have shown modest increases in GLP-1 levels and appetite suppression after capsaicin consumption

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However, this was predominantly driven by one trial, DECLARE TIMI 58, which included healthier cohorts than other cardiovascular outcome trials (CVOT) involving SGLT-2 inhibitors [103], and this benefit of asthma risk reduction was neutralized when DECLARE TIMI 58 was excluded from the analysis [105]