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On average, during the first year, those taking lorcaserin lost around 5.449 kg, while those taking the placebo lost around 2.2 kg
More serious but rare adverse events include pancreatitis (0.2% incidence), gallbladder disease requiring surgical intervention, and medullary thyroid carcinoma risk in genetically predisposed individuals (contraindicated in patients with personal or family history of MTC or MEN2 syndrome)
Among these, 5 genes (AQP3, AQP5, AQP8, DAZAP1, NT5DC2) were not annotated in the verified tissues, but were confirmed to be related to ferroptosis in humans by consulting the literature 19
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