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Mitochondrial iron accumulation further disrupts redox homeostasis, amplifying oxidative stress and contributing to persistent cellular injury (92)

One study demonstrated that people with severe gum inflammation (periodontitis) had lower Glutathione concentrations

Generally, weight loss of greater than 24% of initial body weight and at a rate greater than 1.5 kg (about 3.3 pounds) per week has been identified as a risk factor for gallstones, but the risk may be mitigated by controlling the rate of weight loss, reducing the length of the overnight fast, and keeping a small amount of fat (at least 7 grams per day) in the diet to improve gallbladder motility (Erlinger 2000)

For most people, the risk of deficiency far outweighs any concerns about excess intake