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Systems-Level Perspective and Biomarker Potential Analyzing the methionine cycle from a systems biology perspective allows for the identification of metabolic bottlenecks, feedback regulation mechanisms, and potential biomarkers for nutritional status, metabolic disorders, and disease risk

This deficiency and mutations in MTHFR have also been linked to recessive spastic paraparesis with complex I deficiency

Health-Related Quality of Life Questionnaires were used for measurements of HRQoL and patients completed the questionnaires themselves

Tolerance to side effects: Individual response varies, so discussing side effect management with a provider is important