"I think the manufacturers were open to this partly for political reasons, but also it was just going to expand their patient population dramatically," said Geoffrey Joyce, a health economist and director of health policy at the USC Schaeffer Center
Combined with PlexusDx's Precision Peptide Genetic Test, patients can explore whether specific peptide pathway variants may help provide context for treatment personalizationthough genetic predispositions should always be interpreted with a qualified healthcare provider
44 The 52-week data from 966 patients with MASH and F1B, F2, or F3 fibrosis in the MAESTRO-NASH trial revealed significant effects of resmetirom on MASH resolution, fibrosis improvement, and LDL cholesterol reduction (NCT03900429), 77 forming the basis for potential FDA approval of resmetirom for MASH treatment
The JAK family comprises four intracellular tyrosine kinases: JAK1, JAK2, JAK3, and TYK2, all of which are essential for relaying cytokine-mediated signals through the STAT pathway