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Importantly, trimetazidines main mechanism of action in boosting mitochondrial energy generation when mitochondrial function is impaired dovetails with previous research highlighting bipolar depression as a state of decreased mitochondrial energy generation [20,21,22,23,24,25]

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A higher exposure to estrogen and/or progesterone might increase the risk for thromboembolism, and a lower exposure might result in failure of birth control [41]