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Higher doses of TM elicited UPR activation in etomoxir-treated cells to an extent comparable to that observed with lower doses in non-etomoxir-treated cells (Figure 2C)

The lower alpha diversitybut not serum LPS levelsalso correlated with increased intestinal permeability, measured by a plasma lactulose/rhamnose ratio 90 min after ingestion of the sugar solution, which is a less validated way to assess intestinal permeability because this one sampling point does not take into account renal clearance