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86 Fracture risk A large French cohort study involving 14 253 VSG patients reported an overall major osteoporotic fracture incidence of 1.70 per 1 000 person-years, with specific rates for distal forearm/wrist (0.82), proximal humerus (0.37), clinical vertebral (0.29), and hip fractures (0.22)
40 Duodenal-jejunal bypass liners This device is an endoscopically implanted impermeable sleeve that blocks nutrient absorption from the duodenum to the proximal jejunum for up to 12 months, mimicking surgical duodenal-jejunal bypass
3.2 Regulation of the Keap1-Nrf2 axis Nrf2, as a leucine zipper nuclear transcription factor, is strongly negatively regulated by Keap1 activity
In some cases, temporary dose reduction, treatment interruption, or discontinuation of tirzepatide may be necessary if symptoms are severe or persistent despite conservative management
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