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To confirm reliability, we repeated the experiments using KL1 from two independent suppliers and one from in-house synthesis

Interestingly, these cells increase their dependence on exogenous asparagine once they have developed resistance to the GLS1 inhibitor, CB-839, suggesting that new therapeutic combinations against glutamine metabolism and its downstream effects may be effective

With these insights obtained from the REDEFINE 1 trial, we plan to further explore the additional weight loss potential of CagriSema. However, CagriSemas performance was below the appoximately 25% weight loss Novo had expected, according to a report from Reuters last month

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