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Monoamine Oxidase Inhibitors (MAOIs) The concomitant use of opioids and MAOIs, such as phenelzine, tranylcypromine, or linezolid, may manifest as serotonin syndrome, or opioid toxicity (e.g., respiratory depression, coma) (see WARNINGS)

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Serum Pyk2 levels are negatively correlated with iron levels, and targeted inhibition of Pyk2 can alleviate S-ALI in mice, reduce inflammatory responses, and regulate the expression of ferroptosis-related proteins (such as GPX4 and ACSL4) (Wang et al., 2023d)