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This effect contributes to its potential neuroprotective and cardioprotective benefits

A large 2022 trial that monitored digestive side effects found a median duration of constipation of 47 days in people on semaglutide, compared with 35 days on placebo, suggesting the effect often persists for weeks during dose escalation and early maintenance

Some symptoms of heart failure are: shortness of breath being easily fatigued after walking weight gain edema or peripheral edema (swelling of the feet, ankles, and legs) Kidney problems: Worsening kidney problems with Januvia have been reported