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6) Spiering BA et al

Under normal conditions, Hcy concentrations in plasma and tissues are low (515 M) as a result of remethylation and transsulfuration pathways that are coupled to B-vitamin (B12, folate, B6) and betaine metabolisms 6,7,8

Hematology referral is appropriate for suspected clotting disorders, platelet dysfunction, bone marrow problems, or unexplained thrombocytopenia

Acknowledgements These studies were supported by NIH NCI grant CA166440 (HVH) and a Department of Defense Prostate Cancer Research Program Early Investigator Award (UD)