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Upon measuring grip strength, the researchers found that treatment on its own in sedentary mice increased grip strength by about 25%, compared to exercise alone increasing grip strength by about the same percentage

13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig