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What to Expect in Month 1 Appetite changes: Noticeable suppression begins week 3-4 for most Mild nausea: 40% experience some nausea, usually mild Injection site reactions: Redness, itching, or mild pain at injection site (14% of patients) Fatigue: Some patients report low energy as body adjusts Bowel changes: Either constipation or looser stools as medication affects gut motility 4 Essential Strategies for Month 1 1

Pricing and availability are subject to change

1 To help patients understand dosing with KESIMPTA, share the instructions below: Initial dosing of 20 mg by SC injection at weeks 0, 1, and 2, followed by subsequent dosing of 20 mg by SC injection once monthly starting at week 4

Unlike other growth hormone secretagogues (like GHRP-6, which increases prolactin and causes water retention), Ipamorelin stimulates GH without raising cortisol or prolactin levels