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Graphical Abstract 1 Introduction Inflammatory lung injury is a common pathological feature observed in various pulmonary diseases, including pneumonia, acute respiratory distress syndrome (ARDS), and chronic obstructive pulmonary disease (COPD) ( Emerging evidence suggests that metabolic reprogramming plays a pivotal role in regulating the immune response during pulmonary inflammation ( Carnosine, a naturally occurring dipeptide composed of -alanine and histidine, has been implicated in antioxidative, anti-inflammatory, and cytoprotective processes in various disease models ( in vivo and in vitro

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