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Allosteric modulation Comparing the structures of GLP-1(9-36)GLP-1R with and without LSN3318839 reveals significant spatial overlaps between the first N-terminal helical turn of GLP-1(9-36) (residues T11 P S14 P ) and LSN3318839, with F12 P being the most prominent overlay ( Fig

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The conventional concern that glucagon raises blood glucose and would offset the glucose-lowering goal of GLP-1/GIP agonism is addressed in the published mechanism literature by examining the tissue-specific and timing-specific actions of each receptor arm

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