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3.2 Response surface analysis 3.2.1 Response surface plot showing the effect of concentration of span 60 (A), cholestrol (B) and sonication time (C) on particle size (PS) For effective brain targeting, it is critical to maintain the particle size (PS) of niosomes within the range of 100300 nm

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Ribas GS, Vargas CR, Wajner M (2014) L-carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders