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In 2025, Novo Nordisks semaglutide awaits several first-time FDA decisions: Injectable GLP-1s 2025 Ozempic for T2DM and peripheral artery disease (PAD) 2H 2025 Wegovy for heart failure with preserved ejection fraction (HFpEF) and obesity Oral GLP-1s October 2025 new indication for oral Rybelsus for secondary CV risk reduction 4Q 2025 the first oral GLP-1 ( oral formulation of Wegovy 25 mg ) for weight loss and weight loss plus secondary CV risk reduction Given the considerable continued growth expected in the GLP-1 pipeline, Prime Therapeutics (Prime) talented team of clinical experts actively monitors this emerging landscape

Maxwell, Assistant Professor, Department of Surgical Oncology, University of Texas MD Anderson Cancer Center (prior mentee of James Howe) Diversity, Equity & Inclusion Award- Udhayvir Singh Grewal, Clinical Assistant Professor, Department of Hematology and Oncology, Winship Cancer Institute of Emory University (prior mentee of Chandrikha Chandrasekharan) Neuroendocrine Tumor Research Foundation (NETRF) Symposium 2025, Boston, MA

doi: 10.1016/j.mad.2020.111385 382 BehanWMMoreIABehanPO

Understanding the safety profile and potential interactions between these medication classes is essential for optimizing patient outcomes and minimizing adverse events