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For two decades, nobody outside the company could see how it had turned out until 2026, when the FDA put the numbers into a public document

Interestingly, DKO cells also failed to proliferate in dialyzed serum (dFBS), which removes small molecules using a 10,000 MW cutoff membrane (Supplemental Figure 3G)

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These ECM components undergo modifications by binding with soluble factors, including growth factors and other ECM-associated proteins (Ryan et al., 2007)