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A substantial proportion of patients treated with semaglutide achieved clinically significant weight loss thresholds (5%, 10%, 15%), with these benefits appearing to be maintained over time, as indicated by data from the SUSTAIN 5 trial [62], which employed a different drug (PHEN/TPM CR)
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M.MellbinL.JohansenP.LawsonJ.PaineA.SandbergA
Rather than acting solely through weight loss or peripheral glucose control, GLP-1 therapies engage neural pathways involved in energy regulation, inflammation, synaptic integrity, and protein homeostasisoffering a biologically coherent explanation for their emerging association with preserved cognitive function and reduced dementia risk
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