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Moreover, pramlintide promotes satiety and reduces caloric intake by acting on hypothalamic centers involved in appetite regulation, making it particularly beneficial for individuals with diabetes who struggle with weight management

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The standard approach follows a four-week ramp-up schedule: Week 1: One tablet (8mg naltrexone / 90mg bupropion) in the morning Week 2: One tablet in the morning, one in the evening Week 3: Two tablets in the morning, one in the evening Week 4 onward (maintenance): Two tablets in the morning, two in the evening The full contrave dose for weight loss at maintenance is four tablets per day two in the morning, two at night