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Side Effects and Safety Side effects Across preclinical studies and the small human trials published to date (~28 subjects across pilot studies), the reported adverse events stay limited: Mild injection-site irritation (rare) No systemic toxicity at therapeutic doses in published reports Oral administration: mild GI upset in sensitive individuals No immunosuppression, hormonal disruption, or metabolic side effects have been observed

Liver fat also correlates to each of the components of MetS [69]

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The sensation may be most pronounced following meals or during dose escalation periods, and some patients find that eating smaller, more frequent meals helps minimize this discomfort