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Sci Rep 7:9393 Acknowledgments We thank Jing Zhao for giving some helps in performing the experiments and thank the AJE company for providing the language editing help

For instance, numerous, differentially expressed metabolism-regulating genes in obesity remained remarkably downregulated after significant weight reduction (including IGF-1, LPIN1, IDH1, PDE3A, DUSP1, GPx3, and Glutamine Synthetase genes), while fibrosis- and apoptosis-related pathways linked with TGF- were upregulated [164]

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The concern is that people are meant to be given these under medical supervision, and have the side effects monitored.