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Thakur, Kumar, Ahmed, et al., 2021)

In addition, as migraine prophylactic agents, 400 mg/day of riboflavin was comparable with 500 mg/day of sodium valproate and 100 mg/day of riboflavin was comparable with 80 mg/day of propranolol, with no statistical differences between groups in their prophylactic actions, with a more favorable side effect profile in the riboflavin groups (100)

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The mixture was stirred for 24 h to activate the carboxylic groups