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Experiments on high fat diet induced obese mice by Ding et al., 2018 indicate that the administration of resveratrol (RES), a polyphenol predominantly present in grapes and mulberries, enhances CCR2 expression in white adipose tissue, mitigates inflammation, and diminishes macrophage infiltration, thereby improving insulin signaling markers in both subcutaneous and visceral adipose tissue

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Relevant sources include: Alba M, Fintini D, Sagazio A, et al