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Some praise high-profile figures for openly seeking medical help and reducing stigma around obesity treatment

Instead, this may result in several unintended negative consequences

Accordingly, despite losing 25% of their body mass, GLP-1MK-801-treated mice maintained an energy expenditure that was similar to that of vehicle-treated control mice and was therefore also significantly higher than the gradually decreasing energy expenditure observed in mice that were calorie-restricted to match the weight loss trajectory of GLP-1MK-801-treated mice

The treatment requires multiple sessions (typically 510), costs between 40,000 and 1,20,000 for optimal results, and demands ongoing maintenance every 23 months