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This free-living microorganism primarily feeds on bacteria but can become pathogenic in humans, causing an extremely rare, sudden, severe, and usually fatal brain infection known as naegleriasis or primary amoebic meningoencephalitis (PAM)

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Many of these medications can be used on a short- or long-term basis in combination with lifestyle changes

In mammalian cells, the UPR is a highly conserved cellular signaling response, which is composed of three ER transmembrane proteins: inositol-requiring kinase 1 (IRE1), double-stranded RNA-dependent protein kinase-like ER kinase (PERK) and activating transcription factor-6 (ATF6)