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Semaglutide and tirzepatide may impact mood and anxiety, but their effects can differ widely between individuals

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One hundred micrograms of biotinylated anti-pan HLA class II antibody Tu39 (BD Biosciences Cat# 555556, RRID:AB_395938) or anti-HLA-DR antibody L243 (Sigma-Aldrich Cat# SAB4700731, RRID:AB_3676496) was immobilized on streptavidin cartridges (Agilent) by passing over the cartridge at 5 l/min