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In our model, NAPQI is produced in the liver by three cytochrome oxidases, CYP2E1, CYP3A4, and CYP1A2

The dual incretin mechanism GLP-1 receptor agonists engage the GLP-1 receptor across the pancreas, hypothalamus, and gastrointestinal tract, slowing gastric emptying, blunting post-meal glucose spikes, reducing appetite, and increasing satiety signaling

The contents of the cecum were mixed with sterilized water at a rate of 0.25 g per 1 ml and centrifuged at 13,000 g for 15 min, and then 100 l of supernatant was used