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J Gen Virol

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ROS generation in spermatozoa Oxidative stress, and its role in the origins of male infertility was first appreciated in 1943, when the Scottish andrologist John MacLeod demonstrated that catalase could support the motility of human spermatozoa incubated under aerobic conditions [15]

IGF-1 and its receptor IGF-1R are involved in these critical pathways and therefore play a pivotal role in healthy tissue homeostasis but also a far less desirable role in diseases such as cancer where they can be responsible for the survival and proliferation of malignant cells