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However, this pathway is reported to be inactive in most tissues, and in the few tissues in which it is active, its function is reduced in tumours from the corresponding tissue 16

Reactive oxygen species (ROS) are generated as byproducts during thyroid hormone synthesis [12]

Its role in generating superoxide and scavenging H 2 O 2 will be covered in this review, and the biosynthetic reactions coupled to NADPH will be covered in other reviews in this collection