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This analysis showed that several critical proteins, including Cyp7a1, Scarb1, Pck1, Abcg5, Abcg8, and Nr1h4 were significantly upregulated after post-treatment, indicating enhanced liver function and bile acid metabolism

Furthermore, the primary active metabolite of TGP, paeoniflorin, has low oral bioavailability and is rapidly metabolized, limiting its therapeutic efficacy