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Therefore, the tripeptide is believed to act as a natural feedback signal to fibroblasts, the cells responsible for producing collagen and other ECM components

Intra-articular CD1c-expressing myeloid dendritic cells from rheumatoid arthritis patients express a unique set of T cell-attracting chemokines and spontaneously induce Th1, Th17 and Th2 cell activity

Furthermore, increased mucosal permeability in UC exposes the immune system to bacterial antigens, leading to abnormal immune responses that exacerbate inflammation and disrupt immune regulation

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