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Common symptoms include: Chronic Fatigue: A persistent sense of tiredness that doesnt improve with rest

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By far, it has shown the highest average weight loss results in a clinical trial with 22.5% average weight loss at 72 weeks (SURMOUNT-1, NEJM 2022)

Results were similar when weight change was analysed in participants with or without any of the three common GI AEs that were considered to possibly influence weight loss (nausea, diarrhoea and/or vomiting) (Figure 3)