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It does mean thyroid history is an important topic in any discussion of incretin-based treatment

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Example for 50 mg twice daily (100 mg total daily dose): Days 1-3: 25 mg morning, 50 mg evening Days 4-6: 25 mg morning, 25 mg evening Days 7-9: 25 mg once daily Day 10: Stop completely Long-Term Use (More than 4 weeks, e.g., for chronic anxiety, insomnia, or itching) Slow taper: Reduce by 10-25% every 7-14 days to minimize withdrawal effects