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If the liver is exposed to an excess of APAP, however, these detoxification processes are overwhelmed, and APAP is instead metabolized by the cytochrome P450 enzyme CYP2E1 into the highly reactive and toxic metabolite NAPQI 4

(Baltim., Md.) 70 , 711724 (2019)

What Makes Glutathione Injections So Desirable

Animal studies show that the metabolites can be toxic to neurons at levels that are much lower than those required for liver damage.[ref][ref] I cant help but think that the times when you give an infant acetaminophen circumcision, shots, and illnesses are also the times when the antioxidant system is already taxed, bringing about two hits to their young detox system