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Typical timeline (results may vary): Weeks 1-4 (Starting phase): Reduced appetite and cravings may begin Some initial weight loss possible Body adjusting to medication Some patients may experience mild nausea (typically temporary) Months 1-3 (Active phase): Gradual weight loss may continue Some patients notice changes in clothing fit Energy levels may improve Months 3-6 (Continued progress): Weight loss may continue Dose optimization as needed Health markers may improve Sustainable habit formation Factors affecting your results: Starting weight and BMI Adherence to medication schedule Diet quality (especially protein intake) Physical activity level Individual metabolic factors Sleep quality and stress management Note: Individual results vary

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doi: 10.1016/j.biopha.2021.111377 56 RondaO.GrzdkaE.OstolskaI.OrzeJ.CielikB

Research consistently shows that successful long-term weight maintenance is challenging but achievable for some individuals with sustained effort