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Every 5 kg of weight loss independently reduces systolic blood pressure by approximately 3 to 5 mmHg, reduces triglycerides, improves HDL cholesterol, reduces insulin resistance, decreases systemic inflammation, and reduces mechanical strain on the heart

"Best Practices for Peptide Storage in Research and Clinical Settings." Pharmaceutical Research , 41(2), 245-258

Among these, semaglutide has demonstrated reduced risk of major adverse cardiovascular events (MACE) in trial participants with moderate or high cardiovascular risk